转化生长因子-β（TGF-β）
转化生长因子-β（TGF-β）超家族包含30多个成员，包括TGF-β、激活素（Activin）、抑制素（Inhibin）、骨形态发生蛋白（BMPs）和生长分化因子（GDFs）。它大致可分为两个亚家族：TGF-β/激活素/ nodal亚家族和BMP/GDF/MIS（缪勒管抑制物）亚家族。该超家族在调节细胞增殖、谱系分化、迁移、黏附和凋亡，以及胚胎发育、细胞外基质形成和骨形成与重塑中发挥着关键作用。这种细胞因子被命名为"TGF-β"，是因为它能诱导正常成纤维细胞的表型转化——具体而言，在表皮生长因子（EGF）存在下，它会改变内壁成纤维细胞的生长特性，使其能够在琼脂中生长，并在生长过程中失去密度依赖性抑制。
TGF-β家族信号通路的失调是多种疾病的基础：过度激活会导致癌症和慢性器官损伤中的免疫逃逸、上皮-间质转化（EMT）和纤维化，而信号不足则会导致骨骼畸形、心血管缺陷和免疫功能障碍。因此，TGF-β配体、受体和Smad蛋白是有价值的疾病生物标志物。
产品列表
| 靶点 | 产品货号 | 产品名称 | 反应性 | 预测分子量 |
|---|---|---|---|---|
| TGFB3 | PHV1914 | Recombinant Human/Mouse/Rat TGFB3 | Human/Mouse/Rat | 12.7 KDa |
| TGF-beta 2 | PHV1624 | Recombinant Mouse/Rat TGF-beta 2 | Mouse/Rat | 12.7 KDa |
| TGF-beta 1 | PHV1622 | Recombinant Mouse/Rat TGF-beta 1 | Mouse/Rat | 12.8 KDa |
| TGFBR2 (C-Fc) | PHM1711 | Recombinant Mouse TGFBR2 (C-Fc) | Mouse | 42.3 KDa |
| TGFBR2 (C-6His) | PHM1710 | Recombinant Mouse TGFBR2 (C-6His) | Mouse | 16.2 KDa |
| Latent TGF Beta-1 (N-6His) | PHH1709 | Recombinant Human Latent TGF Beta-1 (N-6His) | Human | 29.3&12.8 KDa |
| TGFBR2 (C-Fc) | PHH1625 | Recombinant Human TGFBR2 (C-Fc) | Human | 42.6 KDa |
| TGF-beta 2 | PHH1623 | Recombinant Human TGF-beta 2 | Human | 12.7 KDa |
| TGF-beta 1 | PCH1621 | Recombinant Human TGF-beta 1 | Human | 12.8 KDa |
GDF-8 | Recombinant Human/Mouse/Rat GDF-8 | Human/Mouse/Rat | 13.1 kDa | |
GDF15 (N-8His-Flag) | Recombinant Mouse GDF15 (N-8His-Flag) | Mouse | 16.9 kDa | |
BMP-7 | Recombinant Human BMP-7 | Human | 15.5 kDa | |
| GDF-11 | Recombinant Human GDF-11 | Human | 12.5 kDa | |
| BMP-2 | Recombinant Human/Mouse/Rat BMP-2 | Human/Mouse/Rat | 13.3 kDa | |
| BMP-4 | Recombinant Human BMP-4 | Human | 13.3 kDa | |
| Persephin | PEH1312 | Recombinant Human Persephin | Human | 10.4 kDa |
| GDF-5 | PEH0722 | Recombinant Human GDF-5 | Human | 13.7 kDa |
验证数据
相关产品
参考文献
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