肿瘤坏死因子 (TNFs）及其受体
肿瘤坏死因子超家族（TNFSF）是一组在生物学中发挥广泛而重要作用的蛋白质。目前，该家族已鉴定出19个配体，如TNF-α、TNF-β、CD40L、FasL、TRAIL、RANKL等，对应的受体有29个。TNFSF成员均为II型跨膜蛋白，其C末端含有TNF同源结构域，可促进配体与受体三聚体复合物的形成，从而激活细胞内信号通路。这些配体通过与不同受体结合，调控多种细胞功能，包括免疫应答、炎症反应、细胞增殖、分化、凋亡和胚胎发育等，在维持机体稳态和应对外界刺激方面发挥关键作用。例如，TNF-α在多种肿瘤中异常表达，可促进肿瘤生长、血管生成、侵袭和转移，同时抑制凋亡；而TRAIL可选择性诱导肿瘤细胞凋亡，成为肿瘤治疗的新靶点。此外，CD40L的过表达与多种自身免疫疾病相关，如红斑狼疮和类风湿关节炎；RANKL/RANK信号异常则与骨质疏松相关。
产品列表
| 靶点 | 产品货号 | 产品名称 | 反应性 | 预测分子量 |
|---|---|---|---|---|
| TNF alpha | PEV1680 | Recombinant Rabbit TNF alpha | Rabbit | 17.59 KDa |
| TNF alpha | PER1678 | Recombinant Rat TNF alpha | Rat | 17.4 KDa |
| TNF alpha | PEM1681 | Recombinant Mouse TNF alpha | Mouse | 16.4 KDa |
| TNF beta | PEH1901 | Recombinant Human TNF beta | Human | 18.8 KDa |
| TNF alpha | PEH1679 | Recombinant Human TNF alpha | Human | 17.5 KDa |
| TNF alpha (N-6His) | PEH1677 | Recombinant Human TNF alpha (N-6His) | Human | 21.8 KDa |
| TNF alpha (C-6His) | PEH1676 | Recombinant Human TNF alpha (C-6His) | Human | 18.5 KDa |
| RANK L V2 | PHM2458 | Recombinant Mouse RANK L V2 | Mouse | 23 KDa |
| OPG (C-10His) | PHM1747 | Recombinant Mouse OPG (C-10His) | Mouse | 45.1 KDa |
| OPG (C-Fc) | PHH1674 | Recombinant Human OPG (C-Fc) | Human | 47.2 KDa |
| RELT (C-Fc) | PHH1423 | Recombinant Human RELT (C-Fc) | Human | 41.4 KDa |
| OPG (C-6His) | PHH1255 | Recombinant Human OPG (C-6His) | Human | 44.65 KDa |
验证数据
相关产品
参考文献
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