| 产品名称 |
Recombinant Mouse FZD2 (C-Fc) |
| 英文名称 |
Frizzled-2/FZD2 |
| 纯度 |
Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 |
<1 EU/µg as determined by LAL test. |
| 蛋白构建 |
Recombinant Mouse Frizzled (Drosophila) Homolog 2 is produced by our Mammalian expression system and the target gene encoding Gln29-Leu168 is expressed with a human IgG1 Fc tag at the C-terminus. |
| Accession |
Q9JIP6 |
| 表达宿主 |
Human Cells |
| 种属 |
Mouse |
| 预测分子量 |
42.9 KDa |
| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, 8% Trehaolse, 0.02% tween 80, pH7.4. |
| 运输方式 |
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 |
Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 复溶 |
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 分子别名 |
| Frizzled-2; Fz-2; mFz2; Fzd2;frizzled (Drosophila) homolog 2 |
| 背景介绍 |
| Wnt signaling plays a critical role in embryonic development, and genetic aberrations. Frizzled2 (Fzd2) is a receptor for wingless-type MMTV integration site family members (Wnts), the aberrant overexpression of which has been noted to contribute to cancer metastasis. Frizzled2 (Fzd2) and its ligands Wnt5a/b are elevated in metastatic liver, lung, colon, and breast cancer cell lines and in high-grade tumors and that their expression correlates with markers of epithelial-mesenchymal transition (EMT). It is also shown that Frizzled-2 expression is greater in embryonic than adult tissues, with heart, brain, lung, kidney and gut showing the highest levels. |
注意事项
本司产品仅用于科研，不用于临床诊断和治疗
