| 产品名称 |
Recombinant Rhesus Macaque ICAM-1 (C-Fc) |
| 英文名称 |
ICAM-1/ICAM1/CD54/Intercellular adhesion molecule 1 |
| 纯度 |
Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 |
<1 EU/µg as determined by LAL test. |
| 蛋白构建 |
Recombinant Intercellular adhesion molecule 1 is produced by our Mammalian expression system and the target gene encoding Gln28-Glu480 is expressed with a human IgG1 Fc tag at the C-terminus. |
| Accession |
Q5NKV6 |
| 表达宿主 |
Human Cells |
| 种属 |
Rhesus Macaque |
| 预测分子量 |
76.3 KDa |
| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 运输方式 |
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 |
Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 复溶 |
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 分子别名 |
| Intercellular adhesion molecule 1; ICAM1; ICAM-1; CD54 |
| 背景介绍 |
| Intercellular adhesion molecule 1 (ICAM1) is known as CD54. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and animal models of atherosclerosis. Additionally, ICAM-1 has been implicated in the progression of autoimmune diseases. ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. |
注意事项
本司产品仅用于科研，不用于临床诊断和治疗
