| 产品名称 |
Recombinant Mouse CLEC2D (N-6His) |
| 英文名称 |
CLEC2D/C-type lectin domain family 2 member D |
| 纯度 |
Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 |
<1 EU/µg as determined by LAL test. |
| 蛋白构建 |
Recombinant Mouse C-type Lectin Domain Family 2 Member D is produced by our Mammalian expression system and the target gene encoding Leu63-Ser207 is expressed with a 6His tag at the N-terminus. |
| Accession |
Q91V08 |
| 表达宿主 |
Human cells |
| 种属 |
Mouse |
| 预测分子量 |
17.9 KDa |
| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 运输方式 |
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 |
Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 复溶 |
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 分子别名 |
| C-type lectin domain family 2 member D; C-type lectin-related protein B; Clr-b; Lectin-like transmembrane protein; Osteoclast inhibitory lectin; Clec2d; Clrb; Ocil |
| 背景介绍 |
| C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and immunity. The C-type lectin receptor Clec2d as a sensor of cell death, which directly detects histones released during necrosis and thus contributes to inflammation and immunopathology. The Clec2d pathway may also be exploited to favor a pro-inflammatory anti-tumor response. And tumor cells can show reduced global levels of histone modification, which may favor Clec2d sensing. The contrasting expression of CLEC2D in HIV infection and pre-eclampsia is demonstrative of the immunosuppressive and pro-inflammatory roles of the respective pathologies. |
注意事项
本司产品仅用于科研，不用于临床诊断和治疗
