| 产品名称 |
Recombinant Mouse CD5L (C-6His) |
| 英文名称 |
CD5 antigen-like/CD5L |
| 纯度 |
Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 |
<1 EU/µg as determined by LAL test. |
| 蛋白构建 |
Recombinant Mouse CD5 Antigen-like is produced by our Mammalian expression system and the target gene encoding Glu22-VaL352 is expressed with a 6His tag at the C-terminus. |
| Accession |
Q9QWK4 |
| 表达宿主 |
Human Cells |
| 种属 |
Mouse |
| 预测分子量 |
37.43 KDa |
| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 运输方式 |
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 |
Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 复溶 |
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 分子别名 |
| CD5 antigen-like;Apoptosis inhibitor expressed by macrophages;Apoptosis inhibitory 6;CT-2;SP-alpha;Cd5l;Aim; Api6 |
| 背景介绍 |
| CD5L, also known as CD5 antigen-like, is secreted protein which mainly expressed by macrophages in lymphoid and inflammed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. It is able to inhibit lipid droplet size in adipocytes. CD5L acts as a key regulator of metabolic switch in T-helper Th17 cells. It is Participates in obesity-associated autoimmunity via its association with IgM, interfering with the binding of IgM to Fcalpha/mu receptor and enhancing the development of long-lived plasma cells that produce high-affinity IgG autoantibodies. It also acts as an inhibitor of apoptosis in macrophages: promotes macrophage survival from the apoptotic effects of oxidized lipids in case of atherosclerosis. It is involved in early response to microbial infection against various pathogens by acting as a pattern recognition receptor and by promoting autophagy. |
注意事项
本司产品仅用于科研，不用于临床诊断和治疗
