| 产品名称 |
Recombinant Mouse GITR (C-Fc-6His) |
| 英文名称 |
GITR/TNFRSF18/CD357/Tumor necrosis factor receptor superfamily member 18/Glucocorticoid-induced TNFR-related protein/AITR |
| 纯度 |
Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 |
<1 EU/µg as determined by LAL test. |
| 蛋白构建 |
Recombinant Mouse Glucocorticoid Induced TNF Receptor Family Related Gene is produced by our Mammalian expression system and the target gene encoding Ser22-His153 is expressed with a human IgG1 Fc, 6His tag at the C-terminus. |
| Accession |
O35714 |
| 表达宿主 |
Human Cells |
| 种属 |
Mouse |
| 预测分子量 |
42.3 KDa |
| 制剂 |
Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 50 mM NaCl, 5% Sucrose, 5% Dextran-70，0.05% Tween 80, pH8.0. |
| 运输方式 |
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 |
Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 复溶 |
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 分子别名 |
| Tumor necrosis factor receptor superfamily member 18;Glucocorticoid-induced TNFR-related protein;Tnfrsf18; AITR;CD357;GITR-D;TNFRSF18 |
| 背景介绍 |
| Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA、isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6 and binds through its C-terminus to SIVA1/SIVA.It preferentially expressed in activated T lymphocytes and up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation. |
注意事项
本司产品仅用于科研，不用于临床诊断和治疗
