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kinesin family member 4B(KIF4B) Homo sapiens This gene is an intronless retrocopy of kinesin family member 4A. The protein encoded by this gene is a microtubule-based motor protein that plays vital roles in anaphase spindle dynamics and cytokinesis. [provided by RefSeq, Jul 2016],function:Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the kinesin-like protein family.,similarity:Belongs to the kinesin-like protein family. Chromokinesin subfamily.,similarity:Contains 1 kinesin-motor domain.,subcellular location:Not present in the nucleolus. In early mitosis, associated with the mitotic spindle, in anaphase, localized to the spindle midzone and, in telophase and cytokinesis, to the midbody. In late cytokinesis, found in the center of the midbody. Associated with chromosomes at all stages of mitosis.,subunit:Interacts with unphosphorylated PRC1 during late mitosis.,tissue specificity:Highly expressed in hematopoietic tissues, fetal liver, spleen, thymus and adult thymus and bone marrow. Lower levels are found in heart, testis, kidney, colon and lung.,tissue specificity:Specifically expressed in testis.,
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