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The protein encoded by this gene is a beta-amyloid peptide-binding protein. It contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be important in heterotrimeric G protein activation. Beta-amyloid peptide has been established to be a causative factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimer's disease. This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death. Several transcript variants have been found for this gene. [provided by RefSeq, Feb 2016],caution:Was initially thought (PubMed:11278849) to modulate beta-amyloid toxicity by coupling to G protein. However, PubMed:12836168 showed that this effect is not direct.,function:May participate to beta-amyloid-induced apoptosis via its interaction with beta-APP42.,PTM:N-glycosylated.,similarity:Belongs to the TM2 family.,subunit:Interacts with beta-APP42 (beta-amyloid protein 42) peptide of APP.,tissue specificity:Widely expressed.,
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