| 产品名称 |
Recombinant Mouse Kirrel1 (C-6His) |
| 英文名称 |
Kirrel1/NEPH1/nephrin-like protein 1 |
| 纯度 |
Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 |
<1 EU/µg as determined by LAL test. |
| 蛋白构建 |
Recombinant Mouse Kin Of IRRE-like Protein 1 is produced by our Mammalian expression system and the target gene encoding Leu48/xadLeu525 is expressed with a 6His tag at the C-terminus. |
| Accession |
Q80W68 |
| 表达宿主 |
Human Cells |
| 种属 |
Mouse |
| 预测分子量 |
53.4 KDa |
| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, 1mM EDTA, PH7.4. |
| 运输方式 |
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 |
Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 复溶 |
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 分子别名 |
| Kin of IRRE-like protein 1;Kin of irregular chiasm-like protein 1;Nephrin-like protein 1;Kirrel1;Neph1 |
| 背景介绍 |
| Kin of irregular chiasm-like protein 1(Kirrel1), also known as Nephrin-like protein 1(Neph1), belongs to the immunoglobulin superfamily. Kirrel1 plays a significant role in the normal development and function of the glomerular permeability. It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1. The knockout of this gene could result in perinatal lethality accompanied by proteinuria, and effacement of glomerular podocytes. Kirrel1 is abundantly expressed in kidney and specifically expressed in podocytes of kidney glomeruli. Its’ subunit interacts with TJP1/ZO-1 and with NPHS2/podocin (via the C-terminus) and interacts with NPHS1/nephrin (via the Ig-like domains). This interaction is dependent on KIRREL glycosylation. Kirrel1 also interacts when tyrosine-phosphorylated with GRB2. |
注意事项
本司产品仅用于科研，不用于临床诊断和治疗
