| 产品名称 |
Recombinant Human HLA-A*0201 TP53 complex Protein (C-10His) |
| 英文名称 |
HLA-A*0201 TP53 complex Protein |
| 纯度 |
Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 |
<1 EU/µg as determined by LAL test. |
| 蛋白构建 |
Recombinant Human HLA-A*0201 TP53 complex Protein is produced by our Mammalian expression system and the target gene encoding (HMTEVVRHC)(R175H)&Ile21-Met119&Gly25-Ile308 (Ala269Val) is expressed with a 10His tag at the C-terminus. |
| Accession |
P61769&A0A140T913 |
| 表达宿主 |
Human cells |
| 种属 |
Human |
| 预测分子量 |
49.1 KDa |
| 制剂 |
Lyophilized from a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, 1mM EDTA, pH 7.4. |
| 运输方式 |
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 |
Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 复溶 |
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 分子别名 |
| MHC, HLA-A*0201 TP53 complex Protein |
| 背景介绍 |
| Cellular tumor antigen p53, is also known as TP 53, is the most frequently mutated gene across all cancers and encodes the tumor suppressor p53 protein. There is a neoepitope of TP53 which is p53R175H HMTEVVRHC. TP53 protein is degraded by the proteasome into peptides, some of which can be presented on the cell surface by human leukocyte antigen (HLA). The p53R175H /HLA-A*02:01 complex is a particularly attractive therapeutic target, shared by many cancer patients. |
注意事项
本司产品仅用于科研，不用于临床诊断和治疗
