| 产品名称 |
Recombinant Human CD161 (C-6His) |
| 英文名称 |
CD161 |
| 纯度 |
Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 |
<1 EU/µg as determined by LAL test. |
| 蛋白构建 |
Recombinant Human Killer cell lectin-like receptor subfamily B member 1 is produced by our Mammalian expression system and the target gene encoding Gln67-Ser225 is expressed with a 6His tag at the C-terminus. |
| Accession |
AAI14517.1 |
| 表达宿主 |
Human cells |
| 种属 |
Human |
| 预测分子量 |
20.1 KDa |
| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 运输方式 |
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 |
Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 复溶 |
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 分子别名 |
| Killer cell lectin-like receptor subfamily B member 1; KLRB1; CLEC5B; NKRP1A; CD161; Natural killer cell surface protein P1A; NKR-P1A; HNKR-P1a; C-type lectin domain family 5 member B; KLRB1 |
| 背景介绍 |
| Killer cell lectin-like receptor subfamily B, member 1(KLRB1) is a single-pass type II membrane protein which contains 1 C-type lectin domain. KLRB1 plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. It acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. |
注意事项
本司产品仅用于科研，不用于临床诊断和治疗
