产品概述
产品性能
免疫原
产品应用
研究背景
Caution:It is not certain that ARS and ANUP are identical proteins.,Disease:Defects inSLURP1 are a cause of Mal de Meleda (MDM)[MIM:248300]; also known as keratosispalmoplantaris transgradiens of Siemens. MDM is a rare autosomal recessive skin disorder,characterized by diffuse transgressive palmoplantar keratoderma with keratotic lesionsextending onto the dorsa of the hands and the feet (transgrediens). Patients may havehyperhidrosis. Other features include perioral erythema, lichenoid plaques on the knees andthe elbows, and nail abnormalities.,Function:Has an antitumor activity. Was found to be amarker of late differentiation of the skin. Implicated in maintaining the physiological andstructural integrity of the keratinocyte layers of the skin.,induction:Regulated by retinoicacid, epidermal growth factor and interferon-gamma.,similarity:Contains 1 UPAR/Ly6domain.,subunit:Homodimer.,tissue specificity:Granulocytes. Expressed in skin.Predominantly expressed in the granular layer of skin, notably the acrosyringium. Identified in several biological fluids such as sweat, saliva, tears, plasma and urine.
研究领域
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