| 产品名称 |
Recombinant Human PPP1R1A (C-6His) |
| 英文名称 |
PPP1R1A/Protein phosphatase 1 regulatory subunit 1A/IPP-1 |
| 纯度 |
Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 |
<1 EU/µg as determined by LAL test. |
| 蛋白构建 |
Recombinant Human Protein Phosphatase 1 Regulatory Subunit 1A is produced by our E.coli expression system and the target gene encoding Met1-Val171 is expressed with a 6His tag at the C-terminus. |
| Accession |
AAH22470.1 |
| 表达宿主 |
E.coli |
| 种属 |
Human |
| 预测分子量 |
19.98 KDa |
| 制剂 |
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM DTT, 50% Glycerol, pH 8.5. |
| 运输方式 |
The product is shipped on dry ice/polar packs.Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 |
Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 复溶 |
| 分子别名 |
| Protein Phosphatase 1 Regulatory Subunit 1A; Protein Phosphatase Inhibitor 1; I-1; IPP-1; PPP1R1A; IPP1 |
| 背景介绍 |
| Protein Phosphatase 1 Regulatory Subunit 1A (PPP1R1A) is an inhibitor of protein-phosphatase 1. PPP1R1A is a cellular regulator of eIF2 alpha phosphorylation. In hormonal control of glycogen metabolism, IPP-1 protein plays important function. Hormones can elevate intracellular cAMP level and elevate IPP-1 activity. PPP1R1A activation caused cAMP increase , cAMP control over proteins that are not directly phosphorylated by PKA following a rise in intracellular calcium. IPP-1 is inactivated by calcineurin (PP2B). Multiple domains in IPP-1 target cellular PP1 complexes. |
注意事项
本司产品仅用于科研，不用于临床诊断和治疗
