| 产品名称 |
Recombinant K. pneumoniae NEO |
| 英文名称 |
Kanamycin kinase type II/NEO |
| 纯度 |
Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 |
<1 EU/µg as determined by LAL test. |
| 蛋白构建 |
Recombinant Klebsiella Pneumoniae Aminoglycoside 3-phosphotransferase is produced by our E.coli expression system and the target gene encoding Met1-Phe264 is expressed. |
| Accession |
P00552 |
| 表达宿主 |
E.coli |
| 种属 |
Klebsiella pneumoniae |
| 预测分子量 |
29 KDa |
| 制剂 |
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 6%Trehalose, 4%Mannitol, 0.05%Tween80, PH8.0. |
| 运输方式 |
The product is shipped on dry ice/polar packs.Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 |
Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 复溶 |
| 分子别名 |
| Aminoglycoside 3-phosphotransferase; APH(3)-II; APH(3)II; Kanamycin kinase type II; Neomycin-kanamycin phosphotransferase type II; neo |
| 背景介绍 |
| Aminoglycoside 3-phosphotransferase (APH(3)), also known as aminoglycoside kinase, is an aminoglycoside-modifying enzyme and widely presented in resistant bacteria. These ATP-dependent enzymes phosphorylate the 3-hydroxyl of a variety of aminoglycosides including kanamycins, neomycins, paromomycins, neamine, ribostamycin, geneticin, and paromamine. These phosphorylated aminoglycosides fail to bind to their respective ribosomal binding sites with high affinity; hence resistance is conferred to the drugs that are phosphorylated. APH(3) is primarily found in certain species of gram-positive bacteria. |
注意事项
本司产品仅用于科研，不用于临床诊断和治疗
