| 产品名称 |
Recombinant Human Calnexin (C-6His) |
| 英文名称 |
Calnexin/IP90/CANX |
| 纯度 |
Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 |
<1 EU/µg as determined by LAL test. |
| 蛋白构建 |
Recombinant Human Calnexin is produced by our Mammalian expression system and the target gene encoding His21-Pro481 is expressed with a 6His tag at the C-terminus. |
| Accession |
P27824 |
| 表达宿主 |
Human Cells |
| 种属 |
Human |
| 预测分子量 |
53.48 KDa |
| 制剂 |
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 2mM CaCl2, 10% Glycerol, pH 7.5. |
| 运输方式 |
The product is shipped on dry ice/polar packs.Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 |
Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 复溶 |
| 分子别名 |
| Calnexin; IP90; Major Histocompatibility Complex Class I Antigen-Binding Protein p88; p90; CANX |
| 背景介绍 |
| Calnexin/CANX is a single-pass type I membrane protein which belongs to the calreticulin family. It consists of a large N-terminal calcium-binding lumenal domain, a single transmembrane helix and a short (90 residues), acidic cytoplasmic tail. The function of calnexin is to retain unfolded or unassembled N-linked glycoproteins in the endoplasmic reticulum. Calnexin is a calcium-binding protein that interacts briefly with newly synthesized glycoproteins in the endoplasmic reticulum. Calnexin may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. Calnexin seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Calnexin dwindles with aging and might contribute to a cytoprotection in an array of human age-related diseases. |
注意事项
本司产品仅用于科研，不用于临床诊断和治疗
