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The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009],function:May be involved in acute phase reactions.,induction:Levels increase significantly in the sera of patients after different surgical trauma.,PTM:Appears to be both N- and O-glycosylated.,PTM:Cleaved by plasma kallikrein to yield 100 kDa and 35 kDa fragments, and the resulting 100 kDa fragment is further converted to a 70 kDa fragment.,PTM:The O-linked polysaccharides on Ser-696, Thr-701 and Ser-702 are probably the mucin type linked to GalNAc.,similarity:Belongs to the ITIH family.,similarity:Contains 1 VWFA domain.,tissue specificity:Liver specific.,
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