| 产品名称 |
Recombinant Human CD73 (P21589, C-6His) |
| 英文名称 |
CD73/5'-Nucleotidase/5'-NT |
| 纯度 |
Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 |
<1 EU/µg as determined by LAL test. |
| 蛋白构建 |
Recombinant Human 5-Nucleotidase is produced by our Mammalian expression system and the target gene encoding Trp27-Lys547 is expressed with a 6His tag at the C-terminus. |
| Accession |
P21589 |
| 表达宿主 |
Human Cells |
| 种属 |
Human |
| 预测分子量 |
58.8 KDa |
| 制剂 |
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 120mM NaCl, 4mM CaCl2, 20% Glycerol, pH 7.5. |
| 运输方式 |
The product is shipped on dry ice/polar packs.Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 |
Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 复溶 |
| 分子别名 |
| 5-Nucleotidase; 5-NT; Ecto-5-Nucleotidase; CD73; NT5E; NT5; NTE |
| 背景介绍 |
| CD73 is a glycosyl phosphatidylinositol (GPI) anchored membrane protein that belongs to the 5-nucleotidase family. CD73 is an ecto 5Nucleotidase expressed by most cell types. CD73 hydrolyzes extracellular nucleotides into membrane permeable nucleosides. CD73 is one of several enzymes responsible for the production of extracellular adenosine, a signaling molecule that is involved in responses to inflammation and tissue injury. CD73 is a lymphocyte maturation marker that has functions independent of its catalytic activity. CD73 is also a regulator of leukocyte extravasation, a function that requires its 5Nucleotidase activity. Defects in NT5E are the cause of calcification of joints and arteries (CAJA). The recombinant CD73 lacking GPI anchor is secreted as a monomer. |
注意事项
本司产品仅用于科研，不用于临床诊断和治疗
