产品概述
产品性能
免疫原
产品应用
研究背景
This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008],function:Receptor for the CD200/OX2 cell surface glycoprotein. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.,PTM:The mature form of isoform 2 and/or isoform 4 starts at sequence position 27 of the corresponding isoform.,similarity:Belongs to the CD200R family.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with Human herpesvirus 8 vOX2 protein.,tissue specificity:Expressed in granulocytes, monocytes, most T cells, neutrophils, basophils and a subset of NK, NKT and B cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-derived dendritic and mast cells.,
研究领域
Signal Transduction; Signaling Pathway; G Protein Signaling; GPCR; Metabolism; Types of disease; Obesity; Neuroscience; Neurotransmission; Receptors / Channels
