| 产品名称 |
Recombinant Human sCD4 (C-Fc) |
| 英文名称 |
sCD4/T-cell surface glycoprotein CD4 |
| 纯度 |
Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 |
<1 EU/µg as determined by LAL test. |
| 蛋白构建 |
Recombinant Human T-cell Surface Glycoprotein CD4 is produced by our Mammalian expression system and the target gene encoding Lys26-Trp390 is expressed with a human IgG1 Fc tag at the C-terminus. |
| Accession |
P01730 |
| 表达宿主 |
Human Cells |
| 种属 |
Human |
| 预测分子量 |
67.6 KDa |
| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, 1mM EDTA, pH 7.4. |
| 运输方式 |
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 |
Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 复溶 |
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 分子别名 |
| T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3; CD4; Scd4 |
| 背景介绍 |
| CD4 is an approximately 55/xa0kDa type/xa0I transmembrane glycoprotein that is expressed predominantly on thymocytes and a subset of mature T/xa0lymphocytes. It is a standard phenotype marker for the identification of T/xa0cell populations. Mature human CD4 consists of a 371/xa0amino acid extracellular region containing four immunoglobulin-like domains, a 22/xa0aa transmembrane segment, and a 40/xa0aa cytoplasmic domain. CD4 is expressed along with CD8 on double positive T/xa0cells during their development in the thymus. CD4 binds directly to MHC class/xa0II molecules on antigen presenting cells (10). This interaction contributes to the formation of the immunological synapse which is focused around the TCR-MHC class II-antigenic peptide interaction. CD4 also functions as a chemotactic receptor for IL-16 and, in human, as a co-receptor for the gp120 surface glycoprotein of HIV-1. |
注意事项
本司产品仅用于科研，不用于临床诊断和治疗
