| 产品名称 |
Recombinant Human ACVR2B (C-Fc-6His) |
| 英文名称 |
Activin RIIB/ACVR2B/Activin receptor type IIB |
| 纯度 |
Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 |
<1 EU/µg as determined by LAL test. |
| 蛋白构建 |
Recombinant Human Activin Receptor Type 2B is produced by our Mammalian expression system and the target gene encoding Ser19-Thr134 is expressed with a human IgG1 Fc, 6His tag at the C-terminus. |
| Accession |
Q13705 |
| 表达宿主 |
Human Cells |
| 种属 |
Human |
| 预测分子量 |
41.3 KDa |
| 制剂 |
Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 10% Trehalose, 3% Mannitol, 0.05% Tween 80, 10 mM Methionine, pH8.5. |
| 运输方式 |
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 |
Lyophilized protein should be stored at ≤ -20℃, stable for one year after receipt.Reconstituted protein solution can be stored at 2-8℃ for 2-7 days.Aliquots of reconstituted samples are stable at ≤ -20℃ for 3 months. |
| 复溶 |
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 分子别名 |
| Activin Receptor Type-2B; Activin Receptor Type IIB; ACTR-IIB; ACVR2B |
| 背景介绍 |
| Activin proteins that belong to the transforming growth factor-beta (TGF-β) superfamily, exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors. On ligand binding, type I and II receptors form a stable complex, resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity, and subsequently initiates the activation of downstream molecules including the endogenous Smads. ActRIIB, also known as ActRIIB, is a type II receptor containing an extracellular domain (ECD), a transmembrane segment, and a cytoplasmic region that includes the kinase domain. ActRIIB is a receptor for activin A, activin B and inhibin A. Multiple ActRIIB isoforms can also be generated, which bind activin isoforms with different affinities. |
注意事项
本司产品仅用于科研，不用于临床诊断和治疗
