| 产品名称 |
Recombinant Human TREM-2 (C-Fc) |
| 英文名称 |
TREM-2/Triggering Receptor Expressed On Myeloid 2 |
| 纯度 |
Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 |
<1 EU/µg as determined by LAL test. |
| 蛋白构建 |
Recombinant Human Triggering receptor expressed on myeloid cells 2 is produced by our Mammalian expression system and the target gene encoding His19-Ser174 is expressed with a human IgG1 Fc tag at the C-terminus. |
| Accession |
Q9NZC2 |
| 表达宿主 |
Human Cells |
| 种属 |
Human |
| 预测分子量 |
44.4 KDa |
| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 运输方式 |
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 |
Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 复溶 |
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 分子别名 |
| Triggering receptor expressed on myeloid cells 2; TREM2; Triggering receptor expressed on monocytes 2; TREM-2 |
| 背景介绍 |
| TREM2 is a cell surface receptor of the immunoglobulin superfamily. TREM2 is a type-1 transmembrane protein that shuttles to the plasma membrane where it exerts its cell autonomous biological functions. TREM2 undergoes regulated intramembrane proteolysis (RIP). TREM2 is preferentially expressed in microglia and is functionally required for migration, cytokine release, phagocytosis, lipid sensing, ApoE binding, shielding of amyloid plaques, and microglia proliferation in the brian. Most of the functionally investigated mutations are located within the Ig-like domain of TREM2. |
注意事项
本司产品仅用于科研，不用于临床诊断和治疗
