| 产品名称 |
Recombinant Human HOXB4 (L175D, E176K, E178K, N-6His) |
| 英文名称 |
HOXB4 (L175D, E176K, E178K) |
| 纯度 |
Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 |
<1 EU/µg as determined by LAL test. |
| 蛋白构建 |
Recombinant Human Homeobox Protein B4 is produced by our E.coli expression system and the target gene encoding Met1-Leu251 (Leu175Asp, Glu176Lys, Glu178Lys) is expressed with a 6His tag at the N-terminus. |
| Accession |
P17483 |
| 表达宿主 |
E.coli |
| 种属 |
Human |
| 预测分子量 |
29.8 KDa |
| 制剂 |
Supplied as a 0.2 μm filtered solution of 4mM HCl. |
| 运输方式 |
The product is shipped on dry ice/polar packs.Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 |
Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 复溶 |
| 分子别名 |
| Homeobox protein Hox-B4; Homeobox protein Hox-2.6; Homeobox protein Hox-2F; HOXB4; HOX2F |
| 背景介绍 |
| Homeobox B4 (HOXB4) is encoded by the HOXB4 gene which is a member of the the class I homeobox (HOX) gene family and encodes a nuclear protein with a homeobox DNA-binding domain. These genes are master control regulators of developmental programs including embryonic and adult hematopoiesis. Multiple HOX genes, including HOXB4, are highly expressed in the hematopoietic stem cells (HSC) compartment. HOXB4 gene can act in opposite ways when expressed by different cells, promoting the proliferation of stem cells whilst activating the apoptotic pathway in some embryonic structures. The protein HOXB4, as a homeodomain transcription factor, has been shown to be an important regulator of stem cell renewal and hematopoiesis. Incellular or ectopic expression of HOXB4 expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion. |
注意事项
本司产品仅用于科研，不用于临床诊断和治疗
