| 产品名称 |
Recombinant Human FAS (C-Fc) |
| 英文名称 |
CD95/TNFRSF6/FAS |
| 纯度 |
Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 |
<1 EU/µg as determined by LAL test. |
| 蛋白构建 |
Recombinant Human Fibroblast-associated is produced by our Mammalian expression system and the target gene encoding Gln26-Asn173 is expressed with a human IgG1 Fc tag at the C-terminus. |
| Accession |
P25445 |
| 表达宿主 |
Human Cells |
| 种属 |
Human |
| 预测分子量 |
44.6 KDa |
| 制剂 |
Supplied as a 0.2 μm filtered solution of PBS, pH 7.4. |
| 运输方式 |
The product is shipped on dry ice/polar packs.Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 |
Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 复溶 |
| 分子别名 |
| Tumor necrosis factor receptor superfamily member 6; Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor; APT1; FAS1; TNFRSF6 and FAS |
| 背景介绍 |
| FAS(TNFRSF6) is a receptor and contains three TNFR-Cys repeats and one death domain. It has been shown that FAS is involved in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. FADD (adapter molecule) recruits caspase-8 to the activated receptor, the resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis. FAS-mediated apoptosis may play a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. |
注意事项
本司产品仅用于科研，不用于临床诊断和治疗
