产品概述
产品性能
免疫原
产品应用
研究背景
RERG, a member of the RAS superfamily of GTPases, inhibits cell proliferation and tumor formation (Finlin et al., 2001 [PubMed 11533059]).[supplied by OMIM, Mar 2009],disease:Loss of RERG expression may contribute to tumorigenesis in breast. RERG expression is decreased or lost in a significant proportion of primary breast tumors with poor clinical prognosis. High expression of RERG correlates with long relapse-free survival times.,function:Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential.,induction:Up-regulated by estradiol. Down-regulated by tamoxifen.,similarity:Belongs to the small GTPase superfamily. Ras family.,tissue specificity:Detected in heart, brain, placenta, lung, liver, skin, kidney and pancreas. Detected in estrogen receptor-positive breast-derived cell lines, but not in estrogen receptor-negative cell lines.,
研究领域
Signal Transduction; Second Messenger; Nucleotide Messenger; GTP; Signaling Pathway; G Protein Signaling; Small G Proteins; Ras Family; Growth Factors/Hormones; Hormones; Cancer; Oncoproteins/suppressors; Tumor suppressors
