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This gene represents one of a cluster of related genes found on chromosome 17. The proteins encoded by this gene family contain a TBC (Tre-2, Bub2p, and Cdc16p) domain and may be involved in GTPase signaling and vesicle trafficking. [provided by RefSeq, Apr 2014],disease:May be involved in forms of prostate cancers.,function:Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11.,similarity:Contains 1 Rab-GAP TBC domain.,tissue specificity:Expressed in liver, skeletal muscle, kidney, pancreas, spleen, testis, ovary, small intestine and peripheral blood leukocytes. Overexpressed in prostate cancers.,tissue specificity:Expressed in pancreas, thymus and testis.,
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