| 产品名称 |
Recombinant Cynomolgus LAG-3 (C-Fc) |
| 英文名称 |
LAG-3/CD223/Lymphocyte activation gene 3 Protein |
| 纯度 |
Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 |
<1 EU/µg as determined by LAL test. |
| 蛋白构建 |
Recombinant Cynomolgus Lymphocyte Activation Gene-3 is produced by our Mammalian expression system and the target gene encoding Ala18-His449(Pro74) is expressed with a human IgG1 Fc tag at the C-terminus. |
| Accession |
XP_005570011.1 |
| 表达宿主 |
Human Cells |
| 种属 |
Cynomolgus |
| 预测分子量 |
73.6 KDa |
| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, 5% Trehalose, pH 7.4. |
| 运输方式 |
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 |
Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 复溶 |
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 分子别名 |
| Lymphocyte activation gene 3 protein; LAG3; LAG-3; Protein FDC; CD223 |
| 背景介绍 |
| Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4. |
注意事项
本司产品仅用于科研，不用于临床诊断和治疗
