Bcl6 Rabbit Polyclonal Antibody

Bcl6 Rabbit Polyclonal Antibody

规格:50μL 价格:¥1200
规格:100μL 价格:¥2150
应用(Application):WB,IHC-F,IHC-P,ICC/IF,ELISA

种属(Reactivity):Human,Mouse,Rat
偶联物(Conjugate):Unconjugated
基因名(Gene Name):BCL6
SKU: APRab00377 Category: 兔多克隆抗体 Tags: , , , , , , , , , ,

说明书 复制

产品概述

产品名称(Product Name)

Bcl6 Rabbit Polyclonal Antibody

描述(Description)

Rabbit Polyclonal Antibody

宿主(Host)

Rabbit

应用(Application)

WB,IHC-F,IHC-P,ICC/IF,ELISA

种属反应性(Reactivity)

Human,Mouse,Rat

 

产品性能

偶联物(Conjugation)

Unconjugated

修饰(Modification)

Unmodified

同种型(Isotype)

IgG

克隆(Clonality)

Polyclonal Antibody

形式(Form)

Liquid

存放说明(Storage)

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

储存溶液(Buffer)

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

纯化方式(Purification)

Affinity Purification

 

免疫原

基因名(Gene Name)

BCL6

别名(Alternative Names)

BCL6; BCL5; LAZ3; ZBTB27; ZNF51; B-cell lymphoma 6 protein; BCL-6; B-cell lymphoma 5 protein; BCL-5; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51

基因ID(Gene ID)

604

蛋白ID(SwissProt ID)

P41182

 

产品应用

稀释比(Dilution Ratio)

WB: 1:500-1:1000 IHC: 1:50-1:100 IF: 1:50-1:200 ELISA: 1:10000

蛋白分子量(Molecular Weight)

Calculated MW: 79 kDa; Observed MW: 79 kDa

 

研究背景

Bcl-6, a transcriptional repressor, binds Stat recognition-like DNA elements and influences germinal center development and cell differentiation. Additionally, Bcl-6 negatively regulates NFκB expression, thereby inhibiting NFκB-mediated cellular functions.HDAC- and silent information regulator (SIR)-2-dependent acet-ylation of Bcl-6 causes downregulation of activity by inhibiting the ability of Bcl-6 to recruit complexes containing histone deacetylases (HDACs).

 

研究领域

Epigenetics and Nuclear Signaling


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