Phospho-4E BP1 (Thr37) Rabbit Polyclonal Antibody

Phospho-4E BP1 (Thr37) Rabbit Polyclonal Antibody

规格:50μL 价格:¥1350
规格:100μL 价格:¥2250
应用(Application):WB,IHC-P

种属(Reactivity):Human,Mouse,Rat
偶联物(Conjugate):Unconjugated
基因名(Gene Name):EIF4EBP1
SKU: APRab00918 Category: 兔多克隆抗体 Tags: , , , , , , ,

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产品概述

产品名称(Product Name)

Phospho-4E BP1 (Thr37) Rabbit Polyclonal Antibody

描述(Description)

Rabbit polyclonal Antibody

宿主(Host)

Rabbit

应用(Application)

WB,IHC

种属反应性(Reactivity)

Human,Mouse,Rat

 

产品性能

偶联物(Conjugation)

Unconjugated

修饰(Modification)

Phosphorylated

同种型(Isotype)

IgG

克隆(Clonality)

Polyclonal

形式(Form)

Liquid

存放说明(Storage)

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

储存溶液(Buffer)

Liquid in PBS containing 50% glycerol, 0.5% protective protein and 0.02% sodium azide, pH 7.3.

纯化方式(Purification)

Affinity Purification

 

免疫原

基因名(Gene Name)

EIF4EBP1

别名(Alternative Names)

EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I

基因ID(Gene ID)

1978

蛋白ID(SwissProt ID)

Q13541

 

产品应用

稀释比(Dilution Ratio)

WB 1:500-1:1000,IHC 1:50-1:100

蛋白分子量(Molecular Weight)

Calculated MW: 13 kDa; Observed MW: 18 kDa

 

研究背景

Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation. Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity.

 

研究领域

Epigenetics and Nuclear Signaling


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