肺癌信号通路相关抗体列表
肺癌（Lung cancer），也称为肺carcinoma，是一种起源于肺部组织的恶性肿瘤。肺癌通常由气道细胞的DNA受到遗传损伤引起，这些损伤常常是由吸烟或吸入有害化学物质所致。受损的气道细胞获得无限制增殖的能力，导致肿瘤的生长。如果不治疗，肿瘤会扩散至整个肺部，损害肺功能。最终，肺部肿瘤会转移，扩散至身体其他部位。
其病理类型主要分为小细胞肺癌（SCLC）和非小细胞肺癌（NSCLC）两大类。非小细胞肺癌约占所有肺癌病例的80%至85%，而小细胞肺癌约占10%至15%。不同类型的肺癌在发病机制、治疗和预后方面存在差异。
作为全球发病率和死亡率最高的恶性肿瘤之一，其发生发展与多种信号通路的异常激活或抑制密切相关。深入解析这些信号通路的分子机制，对肺癌的早期诊断、分子分型及靶向治疗具有重要意义。
JAK-STAT信号通路
JAK/STAT信号通路在肺癌的发生、发展和转移中发挥重要作用，其异常激活可促进肿瘤细胞的增殖、侵袭和免疫逃逸。
Category | Target | Catalog# | Product Name | Reactivity | Application |
|---|---|---|---|---|---|
| JAK family members | JAK1 | AMRe12815 | JAK1 (9I2) Rabbit Monoclonal Antibody | WB | Human,Mouse,Rat |
| p-JAK1 | AMRe05929 | Phospho-JAK1 (Y1034 + Y1035) (14S9) Rabbit Monoclonal Antibody | WB,IHC-P,IF-P | Human | |
| JAK2 | AMRe21334 | JAK2 Rabbit Monoclonal antibody | WB,IHC,IF,IP,ELISA | Human,Mouse,Rat | |
| p-JAK2 | APRab00831 | Phospho-JAK2 (Tyr1007) Rabbit Polyclonal Antibody | WB,IHC-P,ELISA | Human,Mouse,Rat | |
| JAK3 | AMRe12821 | JAK3 (3T5) Rabbit Monoclonal Antibody | WB,IHC-P,ICC/IF,FC,IP | Human | |
| p-JAK3 | APRab00826 | Phospho-JAK3 (Tyr785) Rabbit Polyclonal Antibody | WB,IHC-P,ELISA | Human,Mouse,Rat | |
| TYK2 | APRab19465 | Tyk 2 Rabbit Polyclonal Antibody | WB,IHC-P,IF-P,IF-F,ICC/IF,ELISA | Human,Mouse,Monkey | |
| STAT family members | STAT1 | AMRe02637 | STAT1 Rabbit Monoclonal Antibody | WB,ICC/IF,IP | Human |
| p-STAT1 | AMRe06018 | Phospho-STAT1 (Y701) (3W10) Rabbit Monoclonal Antibody | WB | Human | |
| STAT2 | AMRe21125 | STAT2 Rabbit Monoclonal antibody | WB,IHC,IF,IP,ELISA | Human,Mouse,Rat | |
| p-STAT2 | APRab05478 | Stat2 (phospho Tyr690) Rabbit Polyclonal Antibody | WB,IHC-P,IF-P,IF-F,ICC/IF,ELISA | Human,Rat | |
| STAT3 | AMRe04144 | STAT3 Rabbit Monoclonal Antibody | WB,IHC-P,ICC/IF | Human,Mouse,Rat | |
| p-STAT3 | AMRe06021 | Phospho-STAT3 (Y705) (13H8) Rabbit Monoclonal Antibody | WB,IHC-P,ICC/IF,FC,IP,IF-P | Human,Mouse,Rat | |
| STAT4 | AMRe03213 | STAT4 Rabbit Monoclonal Antibody | WB,IHC-P,IP | Human | |
| p-STAT4 | APRab05483 | Stat4 (phospho Tyr693) Rabbit Polyclonal Antibody | WB,IHC-P,IF-P,IF-F,ICC/IF,IP,ELISA | Human,Mouse,Rat,Monkey | |
| STAT5 | AMRe18359 | STAT5 (10V11) Rabbit Monoclonal Antibody | WB,IHC-P,ICC/IF,FC,IP,IF-P | Human,Mouse,Rat | |
| p-STAT5 | AMRe21146 | STAT5 (Phospho Tyr694) Rabbit Monoclonal antibody | WB,IHC,IF,IP,ELISA | Human,Mouse,Rat | |
| STAT6 | AMRe18366 | STAT6 (12B11) Rabbit Monoclonal Antibody | WB,IHC-P,ICC/IF,FC,IP,IF-P | Human,Mouse | |
| p-STAT6 | APRab05490 | Stat6 (phospho Tyr641) Rabbit Polyclonal Antibody | WB,IHC-P,IF-P,IF-F,ICC/IF,ELISA | Human,Mouse,Rat | |
Signal pathway regulatory molecules | SHP1 | AMRe02598 | SHP1 Rabbit Monoclonal Antibody | WB,IHC-P | Human |
| SHP2 | AMRe04039 | SHP2 Rabbit Monoclonal Antibody | WB,IHC-P,IP | Human | |
| p-SHP2 | AMRe06005 | Phospho-SHP2 (Y542) (7K17) Rabbit Monoclonal Antibody | WB,ICC/IF,IP | Human,Mouse | |
| PTPN1 | AMRe87672 | PTPN1 Rabbit Monoclonal Antibody | WB, IHC-P, ICC/IF, FC, IP | Human,Mouse,Rat |
TGF-β信号通路
TGF-β信号通路在肺癌的发生、发展和转移中发挥重要作用，其异常激活可促进肿瘤细胞的增殖、侵袭和转移。
| Category | Target | Catalog# | Product Name | Reactivity | Application |
|---|---|---|---|---|---|
| TGF-β receptor | TGFβ RI | APRab18855 | TGFβ RI Rabbit Polyclonal Antibody | WB,IF-P,IF-F,ICC/IF,ELISA | Human,Mouse,Rat |
| TGFβ RII | APRab18857 | TGFβ RIII Rabbit Polyclonal Antibody | WB,IF-P,IF-F,ICC/IF,ELISA | Human,Mouse,Rat | |
| TGF-β ligand | TGF-β1 | AMM00745 | TGF beta 1 (4C1) Mouse Monoclonal Antibody | IHC-P | Human,Rat,Mouse |
| SMAD proteins | SMAD1 | AMRe86652 | Smad1 Rabbit Monoclonal Antibody | WB, IHC-P, FC | Human |
| p-SMAD1 | AMRe06008 | Phospho-Smad1 (Ser463/Ser465) (13F8) Rabbit Monoclonal Antibody | WB,ICC/IF,IP | Human,Mouse | |
| SMAD2 | AMRe17990 | Smad2 Rabbit Monoclonal Antibody | B,IHC-F,IHC-P,ICC/IF,IP | Human,Rat,Hamster | |
| p-SMAD2 | AMRe21461 | Smad2 (Phospho Ser250) Rabbit Monoclonal antibody | WB,IHC,IF,IP,ELISA | Human,Mouse,Rat | |
| SMAD3 | AMRe01502 | Smad3 Rabbit Monoclonal Antibody | WB,IHC-F,IHC-P,ICC/IF | Human,Rat | |
| p-SMAD3 | AMRe03754 | Phospho-Smad3 (Ser423/425) Rabbit Monoclonal Antibody | WB | Human,Rat,Hamster | |
| SMAD2/SMAD3 | AMM03601 | Smad2/3 (6F7) Mouse Monoclonal Antibody | WB,IHC-P | Human,Rat,Mouse | |
| p-SMAD2/SMAD3 | AMRe21074 | Smad2/3 (Phospho Thr8) Rabbit Monoclonal antibody | WB,IF,IP,ELISA | Human,Mouse,Rat | |
| SMAD4 | AMRe21299 | Smad4 Rabbit Monoclonal antibody | WB,IHC,IF,IP,ELISA | Human,Mouse,Rat | |
| SMAD5 | AMRe02614 | Smad5 Rabbit Monoclonal Antibody | WB,IHC-F,IHC-P,ICC/IF | Human,Mouse,Rat | |
| p-SMAD5 | AMRe21103 | SMAD5 (Phospho Ser463/Ser465) Rabbit Monoclonal antibody | WB,IHC,IF,IP,ELISA | Human,Mouse,Rat | |
| SMAD6 | AMM80888 | SMAD6 Mouse Monoclonal Antibody | WB,ELISA | Human | |
| Other related antibodies | ERK1/2 | AMRe83771 | ERK1/2 Rabbit Monoclonal Antibody | WB,IP,ICC,FC | Human,Mouse,Rat |
| p-ERK1/2 | AMRe03751 | Phospho-ERK1/2 (Thr202/Thr185) Rabbit Monoclonal Antibody | WB,IP | Human,Hamster,Rat | |
| JNK1-JNK3 | APRab00131 | JNK1/3 Rabbit Polyclonal Antibody | WB,IP | Human,Mouse,Rat | |
| P70 S6 Kinase α | APRab15665 | p70 S6 kinase α Rabbit Polyclonal Antibody | WB,IHC-P,IF-P,IF-F,ICC/IF,ELISA | Human,Mouse,Rat,Pig | |
| p-P70 S6 Kinase α | APRab05186 | p70 S6 kinase α (phospho Ser418) Rabbit Polyclonal Antibody | WB,IHC-P,IF-P,IF-F,ICC/IF,ELISA | Human,Mouse,Rat | |
| OCT4 | AMRe21385 | Oct-4 Rabbit Monoclonal antibody | WB,IHC,IF,IP,ELISA | Human,Mouse |
Notch信号通路
该通路的异常激活可促进肿瘤细胞的增殖和存活。
| Category | Target | Catalog# | Product Name | Reactivity | Application |
|---|---|---|---|---|---|
| Notch receptor | Notch1 | AMRe21558 | Notch1 Rabbit Monoclonal antibody | WB,IHC,IF,IP,ELISA | Human,Mouse,Rat |
| Notch4 | AMRe02831 | Notch4 Rabbit Monoclonal Antibody | WB | Human | |
| Anti-Jagged-1 | APRab12813 | Jagged1 Rabbit Polyclonal Antibody | IF-P,IF-F,ICC/IF,WB,IHC-P,ELISA | Human,Mouse,Rat | |
| Notch ligand | DLL1 | AMM83190 | DLL1 Mouse Monoclonal Antibody | WB,IHC | Human, Rat |
| DLL3 | AMM82852 | DLL3 Mouse Monoclonal Antibody | WB,IHC,ICC,FC,ELISA | Human, Rat | |
| Jag1 | AMRe12811 | JAG1 (10E17) Rabbit Monoclonal Antibody | WB | Human,Mouse,Rat | |
| Jag2 | AMRe84313 | JAG2 Rabbit Monoclonal Antibody | WB | Human,Mouse |
NF-κB信号通路
NF-κB信号通路在肺癌的发生、发展和免疫逃逸中发挥重要作用，其异常激活可促进肿瘤细胞的增殖、侵袭和免疫逃逸。
| Target | Catalog# | Product Name | Reactivity | Application |
|---|---|---|---|---|
| NF-κB p65 | AMRe03785 | NF-KB p65 Rabbit Monoclonal Antibody | WB,IHC-F,IHC-P,ICC/IF,IP | Human,Mouse |
| IκB alpha | AMRe21140 | IκB-α Rabbit Monoclonal antibody | WB,IHC,IF,IP,ELISA | Human,Mouse,Rat |
| IKK alpha | AMRe04046 | IKK alpha Rabbit Monoclonal Antibody | WB,IP | Human |
| IKK beta | AMRe02147 | IKK beta Rabbit Monoclonal Antibody | WB,ICC/IF | Human,Mouse,Rat |
| NF-κB p105/p50 | AMRe87472 | NFkB p105/p50 Rabbit Monoclonal Antibody | WB, IHC-P | Human,Mouse,Rat |
| NF-κB p100 | AMRe02342 | NF-KB p100 Rabbit Monoclonal Antibody | WB,ICC/IF,IP | Human,Mouse |
| c-Rel | AMRe87663 | c-Rel Rabbit Monoclonal Antibody | WB,IP | Human |
| Rel B | AMRe04107 | Rel B Rabbit Monoclonal Antibody | WB,IP | Human,Mouse,Rat |
| TAK1 | AMRe02664 | TAK1 Rabbit Monoclonal Antibody | WB,IHC-F,IHC-P,ICC/IF | Human,Mouse,Rat |
| TAB1 | AMRe18594 | TAB1 (1R7) Rabbit Monoclonal Antibody | WB,IHC-P,ICC/IF,FC | Human,Mouse,Rat |
| TBK1 | AMRe04145 | TBK1 Rabbit Monoclonal Antibody | WB,IHC-P,ICC/IF | Human,Mouse,Rat |
| TRAF2 | AMRe19182 | TRAF2 (11L12) Rabbit Monoclonal Antibody | WB,IHC-P,ICC/IF | Human |
| TRAF3 | APRab19185 | TRAF3 Rabbit Polyclonal Antibody | WB,ELISA | Human,Mouse |
| TRAF4 | AMRe19186 | TRAF4 (9Q19) Rabbit Monoclonal Antibody | WB,FC | Human,Mouse |
| TRAF6 | AMRe21044 | TRAF6 Rabbit Monoclonal antibody | WB,IHC,IF,IP,ELISA | Human,Mouse,Rat |
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| Voisey Voisey 是EnkiLife的技术支持专家，擅长免疫学和细胞生物学。她致力于为客户提供专业且高效的技术支持。此外，她还参与客户研究领域的研究工作，并为他们设计极具成本效益的解决方案。 |
