RNF4 Mouse Monoclonal Antibody-EnkiLife

RNF4 Mouse Monoclonal Antibody

规格：50μL 价格：￥1350
规格：100μL 价格：￥2250
应用（Application）：WB
种属（Reactivity）：Human
偶联物（Conjugate）：Unconjugated
基因名（Gene Name）：RNF4 SKU: AMM86118 Category: 鼠单克隆抗体 Tags: Mouse, Unconjugated, WB, Human

说明书复制

产品概述

产品名称（Product Name）	RNF4 Mouse Monoclonal Antibody
描述（Description）	Mouse monoclonal Antibody
宿主（Host）	Mouse
应用（Application）	WB
种属反应性（Reactivity）	Human

产品性能

偶联物（Conjugation）	Unconjugated
修饰（Modification）	Unmodified
同种型（Isotype）	Mouse IgG1
克隆（Clonality）	Monoclonal
形式（Form）	Liquid
存放说明（Storage）	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
储存溶液（Buffer）	Purified antibody in PBS with 0.05% sodium azide.
纯化方式（Purification）	Affinity Purification

免疫原

基因名（Gene Name）	RNF4
别名（Alternative Names）	E3 ubiquitin-protein ligase RNF4, 6.3.2.-, RING finger protein 4, Small nuclear ring finger protein, Protein SNURF, RNF4, SNURF
基因ID（Gene ID）	6047
蛋白ID（SwissProt ID）	P78317

产品应用

稀释比（Dilution Ratio）	WB 1:1000-1:2000
蛋白分子量（Molecular Weight）	21.3kDa

研究背景

E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor- mediated transcriptional activation.

研究领域