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PGP9.5 is a single chain transmembraneous glycoprotein which represents the low molecular weight isoform of the Leucocyte Common Antigen (LCA). Hydrolyze isopeptide bonds between the carboxy-terminal glycine of Ub and the ε-amino group of lysine on target proteins and involved in the cotranslational processing of pro-ubiquitin and ribosomal proteins translated as ubiquitin fusions.
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