KIF7 Mouse Monoclonal Antibody-EnkiLife

KIF7 Mouse Monoclonal Antibody

规格：50μL 价格：￥1350
规格：100μL 价格：￥2250
应用（Application）：IHC,ICC
种属（Reactivity）：Human,Mouse,Rat
偶联物（Conjugate）：Unconjugated
基因名（Gene Name）：KIF7 SKU: AMM84937 Category: 鼠单克隆抗体 Tags: Mouse, Unconjugated, IHC, ICC, Human, Mouse, Rat

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产品概述

产品名称（Product Name）	KIF7 Mouse Monoclonal Antibody
描述（Description）	Mouse monoclonal Antibody
宿主（Host）	Mouse
应用（Application）	IHC,ICC
种属反应性（Reactivity）	Human,Mouse,Rat

产品性能

偶联物（Conjugation）	Unconjugated
修饰（Modification）	Unmodified
同种型（Isotype）	Mouse IgG1
克隆（Clonality）	Monoclonal
形式（Form）	Liquid
存放说明（Storage）	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
储存溶液（Buffer）	Purified antibody in PBS with 0.05% sodium azide,0.5%protective protein and 50% glycerol.
纯化方式（Purification）	Affinity Purification

免疫原

基因名（Gene Name）	KIF7
别名（Alternative Names）	kinesin like protein KIF7; EQYK340; kif7
基因ID（Gene ID）	374654
蛋白ID（SwissProt ID）	Q2M1P5

产品应用

稀释比（Dilution Ratio）	IHC 1:50-1:100,ICC 1:50-1:200
蛋白分子量（Molecular Weight）	/

研究背景

Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes . Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation . Involved in the regulation of epidermal differentiation and chondrocyte development .

研究领域