HIF Prolyl Hydroxylases Rabbit Monoclonal Antibody

HIF Prolyl Hydroxylases Rabbit Monoclonal Antibody

规格:50μL 价格:¥1350
规格:100μL 价格:¥2250
应用(Application):WB,IP,IHC,FC

种属(Reactivity):Human
偶联物(Conjugate):Unconjugated
基因名(Gene Name):HIF Prolyl Hydroxylases
SKU: AMRe84748 Category: 兔单克隆抗体 Tags: , , , , , ,

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产品概述

产品名称(Product Name)

HIF Prolyl Hydroxylases Rabbit Monoclonal Antibody

描述(Description)

Recombinant rabbit monoclonal antibody

宿主(Host)

Rabbit

应用(Application)

WB,IHC,FC,IP

种属反应性(Reactivity)

Human

 

产品性能

偶联物(Conjugation)

Unconjugated

修饰(Modification)

Unmodified

同种型(Isotype)

IgG

克隆(Clonality)

Monoclonal

形式(Form)

Liquid

存放说明(Storage)

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

储存溶液(Buffer)

Purified antibody in PBS with 0.05% sodium azide,0.05% protective protein and 50% glycerol.

纯化方式(Purification)

Affinity Purification

 

免疫原

基因名(Gene Name)

HIF Prolyl Hydroxylases

别名(Alternative Names)

EGLN4 ; HIFPH4; Hypoxia inducible factor prolyl 4 hydroxylase; P4H with transmembrane domain; P4htm; PH4; PHD4; Proline 4 hydroxylase; Prolyl hydroxlase domain containing 4;;HIF PH4

基因ID(Gene ID)

蛋白ID(SwissProt ID)

Q9NXG6

 

产品应用

稀释比(Dilution Ratio)

WB 1:1000-1:2000,IHC 1:100-1:200,FC 1:20-1:100,IP 1:20-1:50

蛋白分子量(Molecular Weight)

Calculated MW: 57 kDa ; Observed MW: 47 kDa

 

研究背景

Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.

 

研究领域


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