产品概述
产品性能
免疫原
Immunizing rabbit with a synthetic peptide containing 2 to 5 Gly 4 Ser repeats.
产品应用
研究背景
Anti-G4S linker (B02H1) mAb is produced by immunizing rabbits with a mixture of containing 2 to 5 Gly 4 Ser repeats. The (G4S)n linker is a commonly used linker, which is flexible and resistant to enzyme digestion, and often used to link fusion proteins, such as single-chain variable fragments (scFv) or bispecific antibody. In particular, Anti-G4S linker (B02H1) mAb is expected to react with chimeric antigen receptors (CAR)-T cells contained (G4S)n connexin (n≥2) in the scFv of the extracellular domain
研究领域
The (G4S)n–linker consists of 2~5 repeats of the pentapeptide Gly–Gly–Gly–Gly–Ser. The use of these residues is intended to confer flexibility and minimize the risk for interference of the linker with the proper folding and function of the connected protein domains. The (Gly4Ser)n linker is commonly used on the single-chain Fv (scFv) domain expressed on the surface of chimeric antigen receptors (CAR)-T cells to connect the variable weight (VH) and variable light (VL) domains.
注意事项
For research use only .
