4E BP1 Rabbit Polyclonal Antibody

4E BP1 Rabbit Polyclonal Antibody

规格:20μL 价格:¥600
规格:50μL 价格:¥1200
规格:100μL 价格:¥2150
应用(Application):WB,IHC-P,FC,IP

种属(Reactivity):Human
偶联物(Conjugate):Unconjugated
基因名(Gene Name):EIF4EBP1
SKU: APRab01368 Category: 兔多克隆抗体 Tags: , , , , , , ,

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产品概述

产品名称(Product Name)

4E BP1 Rabbit Polyclonal Antibody

描述(Description)

Rabbit polyclonal Antibody

宿主(Host)

Rabbit

应用(Application)

WB,IHC,FC,IP

种属反应性(Reactivity)

Human

 

产品性能

偶联物(Conjugation)

Unconjugated

修饰(Modification)

Unmodified

同种型(Isotype)

IgG

克隆(Clonality)

Polyclonal

形式(Form)

Liquid

存放说明(Storage)

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

储存溶液(Buffer)

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein

纯化方式(Purification)

Affinity Purification

 

免疫原

基因名(Gene Name)

EIF4EBP1

别名(Alternative Names)

EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I

基因ID(Gene ID)

1978

蛋白ID(SwissProt ID)

Q13541

 

产品应用

稀释比(Dilution Ratio)

WB 1:500-1:1000,IHC 1:50-1:100,FC 1:50-1:100,IP 1:20-1:50

蛋白分子量(Molecular Weight)

Calculated MW: 13 kDa; Observed MW: 15-20 kDa

 

研究背景

Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation. Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity.

 

研究领域

Epigenetics and Nuclear Signaling


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