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研究背景
S100 proteins regulate a variety of cellular processes such as cell growth and motility, cell cycle progression, transcription, and differentiation. S100P, a member of the S100 family, is a 95 amino acid protein. Its expression is increased in a number of tumors including pancreas, lung, breast, and ovary carcinomas in response to transcriptional activation. May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE).
研究领域
