KDM1A (1E5) Mouse Monoclonal Antibody

KDM1A (1E5) Mouse Monoclonal Antibody

规格:20μL 价格:¥600
规格:50μL 价格:¥1200
规格:100μL 价格:¥2150
应用(Application):WB,ICC/IF,IP

种属(Reactivity):Human,Monkey
偶联物(Conjugate):Unconjugated
基因名(Gene Name):KDM1A
SKU: AMM03855 Category: 鼠单克隆抗体 Tags: , , , , , , ,

说明书 复制

产品概述

产品名称(Product Name)

KDM1A (1E5) Mouse Monoclonal Antibody

描述(Description)

Mouse monoclonal Antibody

宿主(Host)

Mouse

应用(Application)

WB,ICC/IF,IP

种属反应性(Reactivity)

Human,Monkey

 

产品性能

偶联物(Conjugation)

Unconjugated

修饰(Modification)

Unmodified

同种型(Isotype)

IgG1

克隆(Clonality)

Monoclonal

形式(Form)

Liquid

存放说明(Storage)

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

储存溶液(Buffer)

Liquid in PBS containing 50% glycerol, 0.5% protective protein and 0.02% sodium azide, pH 7.3.

纯化方式(Purification)

Affinity Purification

 

免疫原

基因名(Gene Name)

KDM1A

别名(Alternative Names)

KDM1A; AOF2; KDM1; KIAA0601; LSD1; Lysine-specific histone demethylase 1A; BRAF35-HDAC complex protein BHC110; Flavin-containing amine oxidase domain-containing protein 2

基因ID(Gene ID)

23028

蛋白ID(SwissProt ID)

O60341

 

产品应用

稀释比(Dilution Ratio)

WB 1:500-1:1000,ICC/IF 1:50-1:200,IP 1:20-1:50

蛋白分子量(Molecular Weight)

Calculated MW: 93 kDa; Observed MW: 110 kDa

 

研究背景

Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes.

 

研究领域

Epigenetics and Nuclear Signaling


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