Tcl1 Rabbit Monoclonal Antibody

Tcl1 Rabbit Monoclonal Antibody

规格:20μL 价格:¥680
规格:50μL 价格:¥1350
规格:100μL 价格:¥2250
应用(Application):WB, IHC-P, ICC/IF, FC

种属(Reactivity):Human
偶联物(Conjugate):Unconjugated
基因名(Gene Name):Tcl1
SKU: AMRe86659 Category: 兔单克隆抗体 Tags: , , , , , ,

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产品概述

产品名称(Product Name)

Tcl1 Rabbit Monoclonal Antibody

描述(Description)

Rabbit Monoclonal antibody

宿主(Host)

Rabbit

应用(Application)

WB, IHC-P, ICC/IF, FC

种属反应性(Reactivity)

Human

 

产品性能

偶联物(Conjugation)

Unconjugated

修饰(Modification)

Unmodified

同种型(Isotype)

IgG

克隆(Clonality)

Monoclonal

形式(Form)

Liquid

存放说明(Storage)

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

储存溶液(Buffer)

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

纯化方式(Purification)

Affinity Purification

 

免疫原

基因名(Gene Name)

Tcl1

别名(Alternative Names)

TCL1

基因ID(Gene ID)

8115

蛋白ID(SwissProt ID)

P56279

 

产品应用

稀释比(Dilution Ratio)

WB: 1:1000-1:5000 IHC-P: 1:100-1:1000 ICC/IF: 1:100-1:200 FC: 1:200-1:500

蛋白分子量(Molecular Weight)

Calculated MW:14 kDa; Observed MW:14 kDa

 

研究背景

Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]

 


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