HLA DMB Rabbit Monoclonal Antibody

HLA DMB Rabbit Monoclonal Antibody

规格:20μL 价格:¥680
规格:50μL 价格:¥1350
规格:100μL 价格:¥2250
应用(Application):WB, IHC-P, ICC/IF

种属(Reactivity):Human
偶联物(Conjugate):Unconjugated
基因名(Gene Name):HLA DMB
SKU: AMRe86207 Category: 兔单克隆抗体 Tags: , , , , ,

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产品概述

产品名称(Product Name)

HLA DMB Rabbit Monoclonal Antibody

描述(Description)

Rabbit Monoclonal antibody

宿主(Host)

Rabbit

应用(Application)

WB, IHC-P, ICC/IF

种属反应性(Reactivity)

Human

 

产品性能

偶联物(Conjugation)

Unconjugated

修饰(Modification)

Unmodified

同种型(Isotype)

IgG

克隆(Clonality)

Monoclonal

形式(Form)

Liquid

存放说明(Storage)

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

储存溶液(Buffer)

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

纯化方式(Purification)

Affinity Purification

 

免疫原

基因名(Gene Name)

HLA DMB

别名(Alternative Names)

RING7; D6S221E

基因ID(Gene ID)

3109

蛋白ID(SwissProt ID)

P28068

 

产品应用

稀释比(Dilution Ratio)

WB: 1:1000-1:5000 IHC-P: 1:100-1:200 ICC/IF: 1:100-1:500

蛋白分子量(Molecular Weight)

Calculated MW:29 kDa; Observed MW:29 kDa

 

研究背景

HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

 


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