GDF15 (6F3) Rabbit Monoclonal Antibody-EnkiLife

GDF15 (6F3) Rabbit Monoclonal Antibody

规格：50μL 价格：￥1350
规格：100μL 价格：￥2250
应用（Application）：WB
种属（Reactivity）：Human
偶联物（Conjugate）：Unconjugated
基因名（Gene Name）：GDF15 SKU: AMRe11381 Category: 兔单克隆抗体 Tags: Human, WB, Unconjugated, Rabbit, -

说明书复制

产品概述

产品名称（Product Name）	GDF15 (6F3) Rabbit Monoclonal Antibody
描述（Description）	Recombinant rabbit monoclonal antibody
宿主（Host）	Rabbit
应用（Application）	WB
种属反应性（Reactivity）	Human

产品性能

偶联物（Conjugation）	Unconjugated
修饰（Modification）	Unmodified
同种型（Isotype）	IgG
克隆（Clonality）	Monoclonal
形式（Form）	Liquid
存放说明（Storage）	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
储存溶液（Buffer）	Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% protective protein.
纯化方式（Purification）	Affinity purification

免疫原

基因名（Gene Name）	GDF15
别名（Alternative Names）	GDF-15; growth differentiation factor 15; MIC-1; MIC1; NAG-1; PDF; PLAB; PTGFB;
基因ID（Gene ID）	9518
蛋白ID（SwissProt ID）	Q99988

产品应用

稀释比（Dilution Ratio）	WB 1:500-1:2000
蛋白分子量（Molecular Weight）	34kDa

研究背景

Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney. Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:23468844, PubMed:29046435). Binds to its receptor, GFRAL, and activates GFRAL- expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (PubMed:28953886). On hepatocytes, inhibits growth hormone signaling (By similarity).