Recombinant Human MDP1 (C-6His)
Alternative NamesMagnesium-dependent phosphatase 1; MDP-1; EC=3.1.3.48
规格参数 Specifications
| 纯度Purity | Greater than 95% as determined by reducing SDS-PAGE |
|---|---|
| 内毒素Endotoxin | <1 EU/µg as determined by LAL test. |
| 蛋白构建Protein Construction | 【Met1-Ala176】序列区间-6HisC 端标签 |
| Accession | Q86V88 |
| 表达宿主Expression Host | Human Cells |
| 种属Species | Human |
| 预测分子量Predicted MW | 21.1 KDa |
| 制剂Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 7.5. |
| 运输方式Shipping | The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存Stability & Storage | Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
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靶点信息 Target Information
| 分子别名Alternative Names | Magnesium-dependent phosphatase 1MDP-1EC=3.1.3.48 |
|---|---|
| 背景介绍Background | MDP1, which is short for nesium-dependent phosphatase 1, is a 176 aa. protein. It has 3 forms by different alternative splicing. This protein belongs to the HAD-like hydrolase superfamily, and usually takes its function with Magnesium. It can be inhibited by vanadate and zinc, and slightly by calcium. MDP1 is a Magnesium-dependent phosphatase which may act as a tyrosine phosphatase. |
| 功能Function | xxx |
| 相关疾病Disease | 相思病 |
| 亚细胞定位Subcellular Location | Membrane; Single-pass type I membrane protein. |
| 数据库链接Databases |
基因功能参考文献3 条
- Results are in line with the hypothesis that in the early phase of ALS, neuroprotective helper T cells infiltrate in the affected areas in the lumbar spinal cord. This was reflected in higher peripheral percentage of CD4(+) helper T cells and higher expression of FOXP3 and IL-2Ralpha. PMID: 29574662
- a significant association was found between IL2RA SNP and susceptibility to alopecia areata in Iranian cohort PMID: 29979892
- The gene polymorphisms at the loci of IL2RA rs2104286 and rs12722489 are closely associated with susceptibility to MS in the Chinese. PMID: 30352019
