| 产品名称 |
Recombinant Human uPA (C-6His) |
| 英文名称 |
uPA/PLAU/Urokinase-Type Plasminogen Activator |
| 纯度 |
Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 |
<1 EU/µg as determined by LAL test. |
| 蛋白构建 |
Recombinant Human Urokinase-Type Plasminogen Activator is produced by our Mammalian expression system and the target gene encoding Ser21-Leu431 is expressed with a 6His tag at the C-terminus. |
| Accession |
P00749 |
| 表达宿主 |
Human Cells |
| 种属 |
Human |
| 预测分子量 |
47.41 KDa |
| 制剂 |
Supplied as a 0.2 μm filtered solution of 20mM HEPES, 2mM CaCl2, 10% Glycerol, pH 7.4. |
| 运输方式 |
The product is shipped on dry ice/polar packs.Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 |
Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 复溶 |
| 分子别名 |
| Urokinase-Type Plasminogen Activator; U-Plasminogen Activator; uPA; PLAU |
| 背景介绍 |
| Recombinant Human Urokinase-Type Plasminogen Activator is a serine protease, which specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. Urokinase-Type Plasminogen Activator is a potent marker of invasion and metastasis in many human cancers associated with breast, colon, stomach, bladder, brain, ovary and endometrium. Human Urokinase-Type Plasminogen Activator is initially synthesized as 431 amino acid precursor with a N-terminal signal peptide residues. The single chain molecule is processed into a disulfide-linked two-chain molecule. There exists two forms A chain, the long A chain contains an EGF-like domain that is responsible for binding of the uPA receptor. The B chain corresponds to the catalytic domain. |
注意事项
本司产品仅用于科研，不用于临床诊断和治疗
