| 产品名称 |
Recombinant Human TSLPR&IL-7RA Heterodimer (C-6His) |
| 英文名称 |
TSLPR&IL-7RA Heterodimer |
| 纯度 |
Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 |
<1 EU/µg as determined by LAL test. |
| 蛋白构建 |
Recombinant Human Thymic Stromal Lymphopoietin Protein Receptor & Interleukin-7 Receptor Subunit Alpha Fusion Protein is produced by our Mammalian expression system and the target gene encoding Gly25/xadLys231&Glu21-Asp239 is expressed with a 6His tag at the C-terminus. |
| Accession |
Q9HC73&P16871 |
| 表达宿主 |
Human Cells |
| 种属 |
Human |
| 预测分子量 |
54.1 KDa |
| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 运输方式 |
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 |
Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 复溶 |
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 分子别名 |
| Cytokine receptor-like factor 2; Cytokine receptor-like 2; TSLP receptor; CRL2; ILXR; TSLPR; Interleukin-7 receptor subunit alpha; IL-7R subunit alpha; IL-7RA; CD127 |
| 背景介绍 |
| The cytokine thymic stromal lymphopoietin receptor (TSLPR) is consisting of a common γ receptor–like chain (TSLPR-γ) and a common interleukin 7 (IL-7) Rα chain that belongs to the type 1 cytokine receptor family. IL-7 and IL-7Ralpha bind the gamma(c) receptor, forming a complex crucial to several signaling cascades leading to the development and homeostasis of T and B cells. TSLP, forming a triple complex of TSLP/TSLPR/IL-7Rα, activates JAK1 and JAK2, thereby resulting in phosphorylation of STAT5A and STAT5B, as well as STAT1, STAT3, and other STAT proteins to a lesser extent, and MAPKs and NF-κB depending on the cell type. |
注意事项
本司产品仅用于科研，不用于临床诊断和治疗
