| 产品名称 |
Recombinant Human Sting (N-Sumo-6His) |
| 英文名称 |
STING/Stimulator of Interferon Genes Protein/Sting/TMEM173 |
| 纯度 |
Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 |
<1 EU/µg as determined by LAL test. |
| 蛋白构建 |
Recombinant Human Stimulator of Interferon Genes Protein is produced by our E.coli expression system and the target gene encoding Val155-Val341 is expressed with a 6His, Sumo tag at the N-terminus. |
| Accession |
Q86WV6 |
| 表达宿主 |
E.coli |
| 种属 |
Human |
| 预测分子量 |
33.8 KDa |
| 制剂 |
Supplied as a 0.2 μm filtered solution of 20mM HEPES, 100mM NaCl, 10% Glycerol, pH8.0. |
| 运输方式 |
The product is shipped on dry ice/polar packs.Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 |
Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 复溶 |
| 分子别名 |
| Stimulator of interferon genes protein;TMEM173;Mediator of IRF3 activation;sting; |
| 背景介绍 |
| Stimulator of Interferon Gene(Sting,TMEM173) belongs to the TMEM173 family. STING is 379 amino acids (aa) in length. It contains an N-terminal cytoplasmic region (aa 1-20), four transmembrane segments (aa 21-173), and a C-terminal cytoplasmic domain (aa 174-379). It ubiquitously expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophagesand. Its subunit structure associated with the MHC-II complex and Interacts with DDX58/RIG-I, MAVS and SSR2, RNF5 and TRIM56 along with TBK1. This type of protein often uses as facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon. |
注意事项
本司产品仅用于科研，不用于临床诊断和治疗
