肺癌信号通路及相关抗体
探索肺癌发生发展中的关键信号通路及相关研究工具
肺癌（Lung cancer），也称为肺carcinoma，是一种起源于肺部组织的恶性肿瘤。肺癌通常由气道细胞的DNA受到遗传损伤引起，这些损伤常常是由吸烟或吸入有害化学物质所致。受损的气道细胞获得无限制增殖的能力，导致肿瘤的生长。
如果不治疗，肿瘤会扩散至整个肺部，损害肺功能。最终，肺部肿瘤会转移，扩散至身体其他部位。其病理类型主要分为小细胞肺癌（SCLC）和非小细胞肺癌（NSCLC）两大类。非小细胞肺癌约占所有肺癌病例的80%至85%，而小细胞肺癌约占10%至15%。不同类型的肺癌在发病机制、治疗和预后方面存在差异。
作为全球发病率和死亡率最高的恶性肿瘤之一，其发生发展与多种信号通路的异常激活或抑制密切相关。深入解析这些信号通路的分子机制，对肺癌的早期诊断、分子分型及靶向治疗具有重要意义。
Wnt/β-catenin信号通路
Wnt/β-catenin信号通路在肺癌的发生、发展、转移和耐药性中发挥重要作用，其异常激活与肺癌的侵袭性、干细胞特性、耐药性密切相关。
| Target | Catalog# | Product Name | Reactivity | Application |
|---|---|---|---|---|
| β-catenin | AMRe03762 | beta Catenin Rabbit Monoclonal Antibody | WB,ICC/IF | Human,Mouse,Rat |
| APC | AMM20409 | APC (18Z17) Mouse Monoclonal Antibody | IHC-P,IHC-F,WB | Human,Mouse,Rat |
| c-Myc | AMRe21557 | c-Myc Rabbit Monoclonal antibody | WB,IHC,IF,IP,ELISA | Human,Mouse,Rat |
| Cyclin D1 | AMRe09589 | Cyclin D1 (10Z18) Rabbit Monoclonal Antibody | WB,IHC-P,ICC/极IF,IP,IF-P | Human,Mouse,Rat |
| LEF1 | AMRe02209 | LEF1 Rabbit Monoclonal Antibody | WB,ICC/IF | Human,Mouse,Rat |
| TCF3 | AMRe83733 | TCF3 Rabbit Monoclonal Antibody | WB,FC | Human |
| TCF4 | AMRe18735 | TCF4 (14L3) Rabbit Monoclonal Antibody | WB,IHC-P,FC,IF-P | Human,Mouse |
| Wnt1 | AMM80766 | WNT1 Mouse Monoclonal Antibody | WB,IHC,ICC,FC,ELISA | Human,Mouse |
| Wnt2 | AMRe83732 | WNT2 Rabbit Monoclonal Antibody | WB | Human,Mouse,Rat |
| Wnt2b | AMRe02774 | Wnt2b Rabbit Monoclonal Antibody | WB,ICC/IF | Human,Mouse,Rat |
| Wnt3 | AMM03546 | Wnt3 (4F11) Mouse Monoclonal Antibody | WB | Transfected |
| Wnt3a | APRab20422 | Wnt3a Rabbit Polyclonal Antibody | WB | Human,Mouse,Rat |
| Wnt5a | AMRe02775 | Wnt5a Rabbit Monoclonal Antibody | WB,ICC/IF | Human |
| Wnt5b | AMRe19923 | Wnt5b (8N15) Rabbit Monoclonal Antibody | WB,FC | Human |
| Wnt10b | 极AMM80777 | WNT10B Mouse Monoclonal Antibody | WB,IHC,ICC,ELISA | Human |
| Wnt16 | AMRe02773 | Wnt16 Rabbit Monoclonal Antibody | WB,IP | Human,Mouse,Rat |
| Frizzled-1 | APRab11139 | Frizzled-1 Rabbit Polyclonal Antibody | WB,IF-P,IF-F,ICC/IF,ELISA | Human,Rat,Mouse,Rice |
| Frizzled-2 | APRab11141 | Frizzled-2 Rabbit Polyclonal Antibody | WB,IF-P,IF-F,ICC/IF,ELISA | Human,Mouse,Rat |
| Frizzled-3 | APRab11142 | Frizzled-3 Rabbit Polyclonal Antibody | WB,IF-P,IF-F,ICC/IF,ELISA | Human,Mouse |
| Frizzled-4 | APRab11143 | Frizzled-4 Rabbit Polyclonal Antibody | IF-P,IF-F,ICC/IF,ELISA | Human,Mouse,Rat |
| Frizzled-5 | APRab11145 | Frizzled-5 Rabbit Polyclonal Antibody | WB,IHC-P,IF-P,IF-F,ICC/IF,ELISA | Human,Mouse,Rat |
| Frizzled-6 | APRab11147 | Frizzled-6 Rabbit Polyclonal Antibody | WB,IHC-P,IF-P,IF-F,ICC/IF,ELISA | Human,Mouse |
| Frizzled-7 | APRab11148 | Frizzled-7 Rabbit Polyclonal Antibody | WB,FC,IF-P,IF-F,ICC/IF,ELISA | Human,Mouse |
| Frizzled-8 | AMRe11137 | Frizzled 8 (11I2) Rabbit Monoclonal Antibody | WB,IHC-P | Human,Mouse,Rat |
| Frizzled-9 | AMRe11138 | Frizzled 9 / CD349 (15O7) Rabbit Monoclonal Antibody | WB | Human,Mouse,Rat |
| Frizzled-10 | APRab11140 | Frizzled-10 Rabbit Polyclonal Antibody | WB,IHC-P,IF-P,IF-F,ICC/IF,ELISA | Human,Mouse,Monkey |
| Frizzled-5/8 | APRab11146 | Frizzled-5/8 Rabbit Polyclonal Antibody | WB,IF-P,IF-F,ICC/IF,ELISA | Human,Mouse,Rat |
| LRP5 | AMRe86485 | LRP5 Rabbit Monoclonal Antibody | WB, IP | Human,Mouse,Rat |
| LRP6 | AMRe13436 | LRP6 (5A10) Rabbit Monoclonal Antibody | WB | Human,Mouse |
| GSK-3β | AMRe03750 | GSK3 beta Rabbit Monoclonal Antibody | WB,IHC-P | Human,Rat,Hamster |
| Axin1 | AMM81858 | AXIN1 Mouse Monoclonal Antibody | ICC,FC,ELISA | Human |
| Axin2 | AMRe01704 | Axin 2 Rabbit Monoclonal Antibody | WB | Human,Mouse,Rat |
KRAS信号通路
KRAS基因突变是肺癌中最常见的致癌基因突变，影响细胞的增殖、分化和存活。
| Target | Catalog# | Product Name | Reactivity | Application |
|---|---|---|---|---|
| KRAS | APRab13128 | K-Ras Rabbit Polyclonal Antibody | WB,IHC-P,IF-P,IF-F,ICC/IF,ELISA | Human,Mouse,Rat |
PI3K-AKT-mTOR信号通路
PI3K/Akt信号通路在肺癌中起着关键作用，其异常激活与肿瘤细胞的增殖、耐药性、血管生成和免疫逃逸密切相关。
| Target | Catalog# | Product Name | Reactivity | Application |
|---|---|---|---|---|
| PI3K p85α | APRab16101 | PI 3-kinase p85α Rabbit Polyclonal Antibody | WB,IHC-P,IF-P,IF-F,ICC/IF,ELISA | Human,Mouse,Rat |
| AKT | AMRe01622 | AKT Rabbit Monoclonal Antibody | WB,ICC/IF | Human,Mouse,Rat |
| mTOR | AMRe05951 | Phospho-mTOR (S2481) (4Y3) Rabbit Monoclonal Antibody | WB,IHC-P,IF-P | Human,Mouse |
Hedgehog信号通路
该通路的异常激活与肿瘤细胞的增殖和存活有关。
| Target | Catalog# | Product Name | Reactivity | Application |
|---|---|---|---|---|
| Shh | AMM81142 | SHH Mouse Monoclonal Antibody | WB,IHC,FC,ELISA | Human,Mouse,Monkey |
| PTCH1 | APRab00420 | PTCH1 Rabbit Polyclonal Antibody | WB,IHC-P,ELISA | Human,Mouse |
| Smoothened | AMRe86750 | Smoothelin Rabbit Monoclonal Antibody | WB, IHC-P | Human,Mouse,Rat |
| GLI1 | AMRe11461 | Gli1 (17P5) Rabbit Monoclonal Antibody | WB | Human |
| GLI2 | AMM83347 | GLI2 Mouse Monoclonal Antibody | IHC | Human |
| GLI3 | AMRe11464 | Gli3 (10W4) Rabbit Monoclonal Antibody | WB,IHC-P,ICC/IF,IF极-P | Human |
| SUFU | AMRe86597 | SUFU Rabbit Monoclonal Antibody | WB, FC | Human,Mouse,Rat |
参考文献
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- Sarapultsev A, Gusev极 E, Komelkova M, et al.. JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions. Mol Biomed. 2023 Nov 8;4(1):40.
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