产品概述
产品性能
免疫原
产品应用
研究背景
Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Bifunctional iron sensor that switches between 2 activities depending on iron availability (PubMed:1946430, PubMed:1281544, PubMed:8041788). Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization (PubMed:1946430, PubMed:1281544, PubMed:8041788, PubMed:23891004). Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA (PubMed:1946430, PubMed:1281544, PubMed:8041788, PubMed:23891004).
研究领域
Cardiovascular; Blood; Signal Transduction; Metabolism; Energy Metabolism; Epigenetics and Nuclear Signaling; DNA / RNA; RNA Processing; Vitamins / Minerals; Pathways and Processes; Metabolic signaling pathways; Nucleotide metabolism; Energy transfer pathways; Energy Metabolism;
