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Phospho-ZAK (Phospho-Ser165) Rabbit Polyclonal Antibody【50ul/100ul买二送一】

Phospho-ZAK (Phospho-Ser165) Rabbit Polyclonal Antibody【50ul/100ul买二送一】

Cat: APRab06118
★ ★ ★ ★ ★
规格：20μL 价格：￥680
规格：50μL 价格：￥1350
规格：100μL 价格：￥2250
应用（Application）：WB
种属（Reactivity）：Human,Mouse,Rat
偶联物（Conjugate）：Unconjugated
基因名（Gene Name）：MLTK ZAK HCCS4
分类: 兔多克隆抗体 标签: , , , , , ,

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产品概述

产品名称（Product Name）

Phospho-ZAK (Phospho-Ser165) Rabbit Polyclonal Antibody

描述（Description）

Rabbit polyclonal Antibody

宿主（Host）

Rabbit

应用（Application）

WB

种属反应性（Reactivity）

Human,Mouse,Rat

 

产品性能

偶联物（Conjugation）

Unconjugated

修饰（Modification）

Phosphorylated

同种型（Isotype）

IgG

克隆（Clonality）

Polyclonal

形式（Form）

Liquid

存放说明（Storage）

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

储存溶液（Buffer）

Liquid in PBS containing 50% glycerol, 0.5% protective protein and 0.02% New type preservative N.

纯化方式（Purification）

Affinity purification

 

免疫原

基因名（Gene Name）

MLTK ZAK HCCS4

别名（Alternative Names）

Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK)

基因ID（Gene ID）

51776

蛋白ID（SwissProt ID）

Q9NYL2

 

产品应用

稀释比（Dilution Ratio）

WB 1:500-1:2000

蛋白分子量（Molecular Weight）

88kDa

 

研究背景

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation by PKN1 and autophosphorylation on Thr-161 and Ser-165.,function:Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at 'Ser-28'.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,subcellular location:Translocates to the nucleus upon ultraviolet B irradiation.,subunit:Homodimer. Interacts with PKN1 and ZNF33A.,tissue specificity:Ubiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for liver, in which isoform 1 is more highly expressed.,

 

研究领域

MAPK_ERK_Growth;MAPK_G_Protein;Tight junction;

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