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Phospho-SIK (Phospho-Thr182) Rabbit Polyclonal Antibody【50ul/100ul买二送一】

Phospho-SIK (Phospho-Thr182) Rabbit Polyclonal Antibody【50ul/100ul买二送一】

Cat: APRab06079
★ ★ ★ ★ ★
规格：20μL 价格：￥680
规格：50μL 价格：￥1350
规格：100μL 价格：￥2250
应用（Application）：WB
种属（Reactivity）：Human,Mouse,Rat
偶联物（Conjugate）：Unconjugated
基因名（Gene Name）：SIK1
分类: 兔多克隆抗体 标签: , , , , , ,

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产品概述

产品名称（Product Name）

Phospho-SIK (Phospho-Thr182) Rabbit Polyclonal Antibody

描述（Description）

Rabbit polyclonal Antibody

宿主（Host）

Rabbit

应用（Application）

WB

种属反应性（Reactivity）

Human,Mouse,Rat

 

产品性能

偶联物（Conjugation）

Unconjugated

修饰（Modification）

Phosphorylated

同种型（Isotype）

IgG

克隆（Clonality）

Polyclonal

形式（Form）

Liquid

存放说明（Storage）

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

储存溶液（Buffer）

Liquid in PBS containing 50% glycerol, 0.5% protective protein and 0.02% New type preservative N.

纯化方式（Purification）

Affinity purification

 

免疫原

基因名（Gene Name）

SIK1

别名（Alternative Names）

Serine/threonine-protein kinase SIK1 (EC 2.7.11.1) (Salt-inducible kinase 1) (SIK-1) (Serine/threonine-protein kinase SNF1-like kinase 1) (Serine/threonine-protein kinase SNF1LK)

基因ID（Gene ID）

150094

蛋白ID（SwissProt ID）

P57059

 

产品应用

稀释比（Dilution Ratio）

WB 1:500-1:2000

蛋白分子量（Molecular Weight）

86kDa

 

研究背景

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-182 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.,function:Transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. Potential role in G2/M cell cycle regulation. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 UBA domain.,subcellular location:Translocates to the cytoplasm on phosphorylation where it binds binding to YWHAZ.,subunit:Binds to and is activated by YWHAZ when phosphorylated on Thr-182.,

 

研究领域

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