| 产品名称 |
Recombinant Human RANK L (N-6His-Flag) |
| 英文名称 |
RANKL |
| 纯度 |
Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 |
<0.01 EU/µg as determined by LAL test. |
| 蛋白构建 |
Recombinant Human Tumor necrosis factor ligand superfamily member 11 is produced by our Mammalian expression system and the target gene encoding Ile140-Asp317 is expressed with a 6His, Flag tag at N-terminus. |
| Accession |
O14788 |
| 表达宿主 |
Human Cells |
| 种属 |
Human |
| 预测分子量 |
25.3 kDa |
| 制剂 |
Supplied as a 0.2 μm filtered solution of 20mM Sodium phosphate, 100mM NaCl, 2mM EDTA, pH6.0. |
| 运输方式 |
0 |
| 稳定性&储存 |
The product is shipped on dry ice/polar packs.Upon receipt, store it immediately at the temperature listed below. |
| 复溶 |
Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening.Please minimize freeze-thaw cycles. |
| 分子别名 |
| CD254; ODF; OPGL; RANK L; TNFSF11; CD254; Osteoclast differentiation factor; Receptor activator of nuclear factor kappa-B ligand; tumor necrosis factor ligand superfamily member 11 |
| 背景介绍 |
| CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitogen-activated protein kinases (MAPK), activating protein 1 (AP-1), and nuclear factor of activated T cells (NFATc1), resulting in the formation of multinucleated bone-resorbing osteoclasts. RANKL is widely expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoblast, mammary gland epithelial cells, prostate and pancreas. |
注意事项
本司产品仅用于科研，不用于临床诊断和治疗
